海洋微生物次生代谢的生理生态效应及其生物合成机制研究

张偲++王发左++杨键

摘 要：研究可望取得海洋微生物新物种、新基因、新结构、新机制和新功能研究的重大突破，全面提升我国海洋微生物次生代谢科学研究的水平。属重要科学前沿交叉综合研究。海洋微生物是最具优势和特色的海洋生物资源。海洋微生物的研究，关乎海洋生物资源的国家权益保障、创新药物的资源安全、生态环境安全与健康修复和国家重大科技战略。海洋微生物次生代谢的研究是创新药物和生态环境健康修复的基础，也是组合生物合成技术的起点。组合生物合成技术将为海洋微生物产业提供健康、快速、和谐发展的新途径。围绕“海洋微生物的特有次生代谢过程及其生物学意义”关键科学问题，选择我国特有海洋环境和特色海洋生态系统的微生物类群，关注物种多样性和遗传多样性，发现具有生理与生态学效应的新颖次生代谢产物，研究海洋微生物的关键次生代谢过程和主要功能基因，揭示生物合成途径和调控机制，发展基因重组技术、代谢工程技术，丰富生物合成基础理论，开发组合生物合成新技术，从而为创新药物和特色环保制品的开发奠定基础。

关键词：海洋微生物 次生代谢 生理生态效应 生物合成

Project Report for Physiological and Ecological Effects and the Biosynthetic Mechanisms of Marine Microbial Secondary Metabolites

Zhang Si Wang Fazuo Yang Jian

（South China Sea Institute of Oceanology， Chinese Academy of Sciences）

Abstract：Novel species， novel genes， novel structures， and novel mechanisms of marine microbes are expected to be achieved to raise the Chinese scientific research level of secondary metabolites from marine microorganisms. This comprehensive project is an interdisciplinary cooperation of frontier sciences. Marine microorganisms are the most advantageous and special marine biological resources. Research on marine microorganisms is linked with security of national marine living resources， innovative drugs， ecological safety and major scientific strategy of our country. Secondary metabolites of marine microorganisms are not only the foundation of innovative medicines and ecological restoration， but also the starting point for the combinatorial biosynthesis. Combinatorial biosynthesis technology will pave a new way of a healthy， rapid and harmonious development of marine microorganisms industry. Concentrating on the key scientific issue，" unique secondary metabolic process and biological significance of marine microorganisms"， microbial community from marine environment of China was selected. We focus on the diversity of species and heredity， unique characteristics of marine ecosystems， physiological and ecological effects on the novel secondary metabolites of marine microbiology， secondary metabolites related genes， and regulatory mechanism of biosynthesis pathways. Based on DNA recombinant technology， metabolic engineering， and biosynthesis theory， combinatorial biosynthesis technology was developed， and will help to lay a foundation for the development of innovative medicines and environmentally friendly products.

Key Words：Marine microorganisms； Secondary metabolites； Physiological and ecological effects； Biosynthesis

阅读全文链接（需实名注册）：http：//www.nstrs.cn/xiangxiBG.aspx？id=48938&flag=1