Effect of warming Yang and removing blood stasis in Chinese medicine on cardiovascular diseases

Xiao-xia Liu, Ming Chu

1 Shandong Jianlian Shengjia Traditional Chinese Medicine Co., LTD., Jianlian General TCM Clinic,Jinan 250001, Shandong Province, China

2 Institute of Jinan Health Education, Jinan 250001, Shandong Province, China

Abstract Objective: To analyze the therapeutic effect of TCM warming Yang and removing blood stasis on cardiovascular diseases. Methods: A total of 130 patients with cardiovascular disease were selected for outpatient treatment. According to the treatment methods, the control group and the observation group were divided into 65 cases each. Western medicine lipid-lowering drugs,vasodilators, antithrombotic drugs and Chinese medicine warming Yang and removing blood stasis drugs were given respectively, and the therapeutic effects of the two groups were compared.Results: The curative effect of observation group was 98.46% (64/65) higher than that of control group 76.92% (50/65). Conclusion: In the treatment of cardiovascular diseases, the effect of TCM warming Yang and removing blood stasis is outstanding, and should be popularized in clinical practice.

Key words: Cardiovascular disease; Chinese medicine warming Yang removing blood stasis method;Curative effect

Introduction

Cardiovascular diseases include cardiomyopathy, valvular disease, vascular disease and electrical conduction disease.The current clinically common cardiovascular diseases are arrhythmia such as atrial premature, ventricular premature, atrial fibrillation, coronary atherosclerotic heart disease and valvular insufficiency, etc. It is more common in middle-aged and elderly patients, but there is a trend of getting younger. If the treatment is not controlled in time, it will pose a serious threat to the life safety of patients. Clinical practice studies have found that the treatment of warming Yang and removing blood stasis in Chinese medicine can have a significant effect on patients with cardiovascular disease. It will be analyzed below.

Materials and Methods

General information

A total 135 patients with cardiovascular disease who were treated in outpatient clinics from February to October 2018 were included in this study and divided into a control group and an observation group according to the treatment method, with 65 cases in each. In the control group, there were 45 males and 20 females, aged 46-72 years old, with an average of (56.4+/-5.2) years old. After diagnosis, premature contractions or atrial fibrillation,mitral and tricuspid regurgitation, coronary heart disease and coronary intervention, heart failure, heart function decline in grade 1, 2, and 3 were observed in 15 cases, 10 cases, 35 cases, and 5 cases, respectively. In the observation group, there were 43 males and 22 females, aged 48-70 years old, with an average of (59.2+/-4.8) years old. After diagnosis, early atrial fibrillation, mitral and tricuspid regurgitation, coronary heart disease and coronary intervention, heart failure, heart function decline in grade one, two, and three were 17 cases, 8 cases, 36 cases, and 4 cases, respectively. Both groups of patients had clinical symptoms: palpitation, palpitations, chest tightness,shortness of breath, insomnia, fatigue, etc. There was no statistically significant difference in general information between the two groups of patients (P>0.5).

Method

Patients in the control group were given conventional western medicines, lipid-lowering drugs, vasodilators,and antithrombotic drugs, such as lovastatin, aspirin, and isosorbide mononitrate sustained-release tablets. Among them, lovastatin application: 20 mg/time, qn; Aspirin: 100 mg/time, qn; Isosorbide mononitrate sustained-release tablets: 40 mg/time; qn. Continue the medication for 8 weeks.

Patients in the observation group were treated with the method of warming Yang and removing blood stasis of traditional Chinese medicine: premature beats and atrial fibrillation were treated with Zhigancao Decoction[1]Addition and subtraction: Prescription: Prepared Liauorice Root 20 g, Ramulus Cinnamomi 15 g, Colla Corii Asini 6 g (melt), Fructus Cannabis 15 g, Fructus Cannabis 9 g, rehmannia dride rhizome 30 g, jujube 10,raw ginseng 20 g, raw oysters 20 g, Rubia Cordifolia 20 g,Rhizoma Atractylodis 15 g, Alisma Orientale 30 g; for mitral and tricuspid valve regurgitation, Gualou Xiebai Guizhi Tang[2]was applied with addition and subtraction:prescription: Guizhi 15 g, Gualou 18 g, scallion white 18 g, magnolia root 10 g, citrus fruit 10 g, raw astragalus 15 g, adenophora 15 g, Rubia Cordifolia 15 g, Rhizoma Atractylodis 15 g, Alisma Orientale 30 g; for coronary heart disease and coronary intervention, Xuefu Zhuyu decoction[3]was applied with addition and subtraction:prescription: Radix Aconiti Lateralis Preparata 15 g,Prepared Liauorice Root 20 g, cassia twig 25 g, dried ginger 10 g, peach kernel 10 g, safflower 25 g, angelica 15 g, red peony 15 g, paeonol 12 g, Chuanqiong 25 g,rehmannia 30 g, citrus aurantium 15 g, Radix Bupleuri 10 g,platycodon 10 g, adenophorum 15 g, sichuan achyranthes 15 g, Rubia Cordifolia 20 g, Rhizoma Atractylodis 15 g,Alisma Orientale 30 g; for heart failure and decreased heart function at level I, II, and III, Sini Decoction[4]and Hezhen Wu Decoction[5]were applied with addition and subtraction: Radix Aconiti Lateralis Preparata 10-20 g,dried ginger 15 g, roasted licorice 25 g, Radix Aconiti Lateralis Preparata 25 g, Poria Cocos 30 g, white peony 15 g, atractylodes 25 g, 10 pieces of ginger, Cinnamon 2 g(infusion), Ginseng 15 g, Astragalus 30 g, Adenophora 15 g,Salvia 30 g, Rubia Cordifolia 15 g, Rhizoma Atractylodis 15 g, Alisma Orientale 30 g. The above prescription is taken once a day, decocted in water, and taken 3 times. Continue the medication for 8 weeks.

Outcome measures

The treatment effect of the two groups of patients was observed and compared after 8 weeks.

Efficacy criteria

Judgment of curative effect of cardiovascular disease[6]:(1) Remarkable effect, medication for 4-6 weeks. The clinical symptoms of palpitation, palpitations, chest tightness, shortness of breath, insomnia, and fatigue basically disappeared, ECG showed normal, cardiac color Doppler ultrasound showed: ejection fraction increased significantly; (2) effective, 6-8 weeks, clinical symptoms of palpitation, palpitations, chest tightness, shortness of breath, Insomnia and fatigue were significantly improved,ECG showed roughly normal, cardiac color Doppler ultrasound showed: ejection fraction increased slightly;(3) Ineffective, after 8 weeks, the clinical symptoms of palpitation, palpitations, chest tightness, shortness of breath, insomnia, and fatigue remained unchanged, ECG showed Abnormal, cardiac color Doppler ultrasound shows: there is no change in ejection fraction, or there is aggravation. Treatment effective rate = apparent rate +effective rate.

Statistical method

The study found that the data was entered into the Excel table and processed with SPSS18.0 statistical software.The technical data was expressed in the number of cases(n) and percentage (%), and thex2test was used. The difference was statistically significant withP<0.05.

Results

After 8 weeks of treatment, 60 cases were markedly effective in the observation group, 4 cases were effective,and 1 case was ineffective; in the control group, 30 cases were markedly effective, 20 cases were effective, and 15 cases were ineffective. Comparing the efficacy of the two groups of patients, the observation group was 98.46%(64/65) higher than the control group 76.92% (50/65), the difference was statistically significant (P<0.05).

Discussion

The incidence of cardiovascular disease has gradually increased in recent years, and there is a trend of younger age, which poses a great threat to the life and health of patients. Clinical treatment is mostly based on drug treatment, although many coronary atherosclerotic stenosis are more than 75% of the patients and patients with refractory atrial fibrillation were treated with PCI and radiofrequency ablation, but the patients continued to take medication after the operation. The common clinical drugs are basically the treatment of blood vessel expansion, anti-platelet aggregation, lipid-lowering, lipidlowering and stabilizing blood lipid plaques, and longterm medication is required. However, clinical treatment has found that many patients have unsatisfactory results after medication or after medication for a period of time.However, the method of warming Yang with traditional Chinese medicine has achieved remarkable curative effect.The traditional Chinese medicine theory holds that: “The heart is the foundation of life, and the transformation of the gods. Its flower is in the face, and it is filled with blood.It is the sun in the sun, which is connected to the summer qi[7]. The heart is in harmony with the pulse. Its glory and color are also its kidneys. The lungs and skins, its hairs are also, its heart is also. The liver is also synonymous with tendons, its claws are also its prosperous claws, and its lungs are governed[8]. The heart is the lord of the internal organs. The spiritual home is also. Its entrails are strong,and the evil spirit can tolerate it. Tolerance will hurt the heart, if the heart is broken, the god will go away, and the god will die. Therefore, all evil lies in the heart. It lies in the envelope of the heart[9]. It shows that the heart belongs to fire, is the foundation of life, is the dwelling place of God, and interacts with the lungs and kidneys. When the kidney water offender weakens the heart fire, it will lower the heart function and cause clinical manifestations such as arrhythmia, palpitations, palpitation, chest tightness,fatigue, shortness of breath, etc., which can cause heart failure over time, clinically common in premature beats,atrial fibrillation, heart failure, heart failure and other diseases of grade one, two, and three; When the evil of wind and cold is felt from the skin, it will affect the heart,and the heart will not be evil, the pericardium will be replaced, and the cold will enter the pericardium, there will be chest tightness, don’t be angry. Shortness of breath,chest and back pain, etc. are common clinically in mitral valve and tricuspid valve insufficiency; heart and blood vessels are in harmony. When the heart fire is weak and cannot promote blood circulation, blood vessels are prone to blockage and there are formed components in the blood. The deposition can lead to blood vessel obstruction,body pain, chest pain, etc., and coronary heart disease,angina pectoris, and myocardial infarction can occur to the heart itself. In severe cases, it can lead to sudden death.The above-mentioned heart diseases are treated with traditional Chinese medicine for warming yang,nourishing qi and nourishing yin, warming yang to eliminate phlegm and removing blood stasis, warming yang to invigorate qi and activating blood, and warming yang to dispel cold and diuresis, and achieved remarkable curative effect. Among them, Guizhi, dried ginger, aconite,asarum, cinnamon, scallion white, etc. are all warmyang medicines: Guizhi: tastes pungent and warm, and mainly promotes qi and cough. Cinnamon: It is sweet in taste, hot in sex, and is a medicine for warming and replenishing yang. It helps the heat and yang, warms the cold and eliminates the cold... Treats all kinds of pains and hernias in the heart Fenben dolphins, etc.; dried ginger:taste pungent, warm in nature, the main temperature is to eliminate cold, regain yang to promote the channel...open the chest and fu organs, xuanmailuo, etc.; aconite: taste pungent and sweet, hot in sex, for Fu Yuan and return to yang , The main medicine for replenishing fire and relieving cold, paofuzi can consolidate the appearance of deficiency, remove the lung family cold syndrome,and produce aconite can remove the cold; asarum: taste pungent and warm, and has a deep function of dispelling wind and cold...opening the chest and stagnation, etc.; Scallion white: bitter taste, warm in nature, essential medicine for smoothness and dissipating masses,attending to chest pain and tingling... warm middle and help yang, etc.[10]. On the basis of warming yang,plus yin and qi medicine Ejiao, Ophiopogon japonicus,Shengdi, jujube, ginseng, raw keel, raw oyster and other drugs can treat arrhythmia, atrial fibrillation, etc.; plus expectorant slip Medicinal herbs such as Gualou, Scallion White, Magnolia officinalis, Citrus aurantium, etc. can treat valvular insufficiency; plus medicines for removing blood stasis and regulating Qi, such as peach kernel,safflower, angelica, red peony root, paeonol, Chuanqiong,Rehmannia aurantium, Citrus aurantium, Bupleurum ,Platycodon grandiflorum, Eupatorium adenophorum,Achyranthes bidentata, madder, etc. can treat coronary heart disease, angina pectoris and coronary restenosis after PCI; plus the diuretic and stasis medicine Poria, white peony, atractylodes, ginger, adenophorum, salvia, madder,Cangzhu, Alisma, etc. can treat heart failure and decreased heart function.

This study can be found that the effective rate of treatment in the observation group is significantly higher than that in the control group, which fully demonstrates that the TCM warm-yang method has achieved more significant effects through dialectical addition and subtraction of corresponding Chinese medicines. It can stabilize the patient’s condition and recover quickly.

In summary, the application of warm-yang drugs in the treatment of cardiovascular diseases can have significant effects and should be further promoted in clinical practice.